Milk thistle oil (silybum marianum)

aged skin rejuvenation

Pack size options: customised package availabe

DOWNLOAD PRODUCT INFO SHEET
  • Milk thistle seed cold-pressed oil is a rich source of essential fatty acids, tocopherols, polyphenols and other bio-active compounds.

  • The herb is regaining popularity as a medicinal plant source suitable for use as an ingredient in cosmetics, functional foods, dietary supplements and herbal medicine.

  • Recent studies stress its potential in reducing the risk factors for metabolic syndrome , protecting the liver functions, providing antioxidant and anti-inflammatory benefits and even offering neuroprotective and antimicrobial activities.




Benefits *

Health Benefits *

  • Metabolic and Cardiovascular: - research in animals indicates that supplementing with cold-pressed milk thistle oil can reduce weight gain, high blood sugar, high blood pressure, inflammation, and liver scarring caused by obesity. This suggests it could be beneficial for treating metabolic syndrome and improving heart health.
  • Liver protection and antioxidation: - multiple studies confirm that the oil protects the liver. This includes preventing damage from toxins, reducing oxidative stress, and restoring normal liver function. These benefits are attributed to its high concentration of antioxidants.
  • Anti-Inflammatory, Anti-arthritic: - cold-pressed oil from milk thistle shows that it can reduce inflammation and arthritis symptoms. The oil is more effective when it comes from younger seeds because they contain a higher level of a beneficial compound called policosanol.
  • Neuroprotective effects: - it also protects nerve cells by shielding them from harmful toxins derived from cholesterol and from oxidative stress, demonstrating benefits for brain health.
  • Antimicrobial & antifungal : - research shows that the oil can limit the growth of several harmful bacteria and fungi, such as Staphylococcus aureus, E. coli, and Candida species, among others.
  • Anticancer activity : - some studies indicate the oil has a moderate ability to kill liver and colon cancer cells in a lab setting, suggesting it could have anticancer potential.

Applications

  • Cosmetics
  • Pharmaceuticals
  • Food additives
  • Functional ingredients
  • Dietary supplements



Contents

Content (INCI): 100% cold-pressed Milk thistle seed oil ( Silybum marianum oil). No additives. Organic raw material is an option.

Story

A Short History of Milk Thistle: The Liver’s Guardian

Long before it had a Latin name or clinical trials behind it, milk thistle grew wild along the sun-drenched hills of the Mediterranean. Its striking purple flowers and sharp-pointed leaves, veined with milky white lines, were more than just decoration—they marked it as a sacred plant, known to ancient healers as a protector of the liver.

In the writings of Dioscorides—the Greek physician of the 1st century AD—milk thistle was praised for its effects on the liver and bile flow. The Romans used it for snake bites and liver-related distress, believing the white “milk” running through its veins was no accident: it symbolized healing.

As herbal knowledge spread through medieval monasteries, milk thistle became a staple of monastic gardens, valued as a remedy for “melancholy” and liver congestion—conditions they believed stemmed from imbalance of the body’s humors.

In traditional German folk medicine, it was known as Mariendistel—the “Mary thistle.” Legend says the white markings on its leaves were the milk of the Virgin Mary, fallen while she nursed the infant Jesus. From this holy symbolism grew a deep reverence for the plant’s purifying and protective powers.

By the 19th century, European physicians were using alcoholic tinctures of milk thistle seeds for jaundice, gallstones, and hepatitis. But it wasn’t until the 1970s, when researchers isolated a group of compounds known as silymarin, that science began to catch up with tradition.

Today, milk thistle is one of the most studied herbal remedies for liver support, known for protecting cells from toxins, reducing inflammation, and aiding in regeneration. Its cold-pressed seed cake—once a by-product—is now valued for its fiber, protein, and antioxidant content, enriching human diets and animal nutrition alike.

From sacred folklore to clinical science, milk thistle has never strayed far from its role as a guardian of the liver and protector of vitality.



* Scientific References: Milk Thistle Seed Oil

  1. Hsin-Hsueh Shen et al. "Milk thistle seed cold press oil attenuates markers of the metabolic syndrome in a mouse model of dietary-induced obesity..": Journal of food biochemistry (2020): e13522 .
  2. A. Hermenean et al. "Antioxidant and hepatoprotective activity of milk thistle (Silybum marianum L. Gaertn.) seed oil.": Open Life Sciences, 10 (2015).
  3. S. Harrabi et al. "Policosanol composition, antioxidant and anti-arthritic activities of milk thistle (Silybium marianum L.) oil at different seed maturity stages.": Lipids in Health and Disease, 17 (2018).
  4. Heba H. Gaber et al. "Biological in Vitro and in Vivo Studies of the Milk Thistle Seed Oil.": Food and Nutrition Sciences (2022).
  5. Anis Chikhoune et al. "Bioactive Potential of Milk Thistle (Sylibum marianum) Seeds and Applicability of Its Edible Oil in Food Processing.": MGIBR 2024 (2024).
  6. Agata Sumara et al. "Comprehensive Review of Seven Plant Seed Oils: Chemical Composition, Nutritional Properties, and Biomedical Functions.": Food Reviews International, 39 (2022): 5402 - 5422.
  7. W. Meddeb et al. "Cytoprotective Activities of Milk Thistle Seed Oil Used in Traditional Tunisian Medicine on 7-Ketocholesterol and 24S-Hydroxycholesterol-Induced Toxicity on 158N Murine Oligodendrocytes.": Antioxidants, 7 (2018).
  8. G. Dogan et al. "Chemical Composition and Biological Activity of Milk Thistle Seeds (Silybum marianum (L.) Gaertn.).": International Journal of Nature and Life Sciences (2022).
  9. Asmaa Badreddine et al. "Antioxidant and neuroprotective properties of Mediterranean oils: Argan oil, olive oil, and milk thistle seed oil.": Oxidative Stress and Dietary Antioxidants in Neurological Diseases (2020).
  10. P. Oliinyk et al. "Milk Thistle Oil and Its Beneficial Effects on the Liver and Hepatic Diseases.": Journal of Biochemicals and Phytomedicine (2024).
  11. Sameh Maaloul et al. "Characterization of Silybum marianum and Silybum eburneum seed oils: Phytochemical profiles and antioxidant properties supporting important nutritional interests.": PLOS ONE, 19 (2024).
  12. S. Bhattacharya et al. "Milk Thistle ( Silybum marianum L. Gaert.) Seeds in Health.": Nuts and Seeds in Health and Disease Prevention (2011): 759-766.
  13. Sherin Ali et al. "The potential of cultivated milk thistle by-products as cancer chemopreventive and anti-inflammatory drugs.": Egyptian Pharmaceutical Journal, 18 (2019): 411 - 418.
  14. W. Meddeb et al. "Tunisian Milk Thistle: An Investigation of the Chemical Composition and the Characterization of Its Cold-Pressed Seed Oils.": International Journal of Molecular Sciences, 18 (2017).
  15. Abd-El-hady et al. "Morphological, chemical characteristics and antioxidant activity of Egypt grown wild milk thistle (Silybum marianum L.) seeds and evaluates their oil in fast frying process comparing with some vegetable oils.": Middle East Journal of Applied Sciences (2019).
  16. M. Kalinowska et al. "Comparing the extraction methods, chemical composition, phenolic contents and antioxidant activity of edible oils from Cannabis sativa and Silybum marianu seeds.": Scientific Reports, 12 (2022).
  17. Paulina M Opyd et al. "Intestinal, liver and lipid disorders in genetically obese rats are more efficiently reduced by dietary milk thistle seeds than their oil.": Scientific Reports, 11 (2021).
  18. M. Bijak et al. "Silybin, a Major Bioactive Component of Milk Thistle (Silybum marianum L. Gaernt.)—Chemistry, Bioavailability, and Metabolism.": Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry, 22 (2017).
  19. Geir Bjørklund et al. "Milk Thistle (Silybum marianum): Potential Role in Cancer Prevention..": Current medicinal chemistry (2025).
  20. Oumayma Iraqi et al. "Exploring the chemical composition, antioxidant, and antibacterial properties of milk thistle (Silybum marianum L.).": Frontiers in Sustainable Food Systems (2025).
  21. Samantha Drouet et al. "A Green Ultrasound-Assisted Extraction Optimization of the Natural Antioxidant and Anti-Aging Flavonolignans from Milk Thistle Silybum marianum (L.) Gaertn. Fruits for Cosmetic Applications.": Antioxidants, 8 (2019).
  22. V. Valková et al. "MILK THISTLE (SILYBUM MARIANUM): A VALUABLE MEDicinal PLANT WITH SEVERAL THERAPEUTIC PURPOSES.": Journal of Microbiology, Biotechnology and Food Sciences (2020).
  23. L. Abenavoli et al. "Milk thistle (Silybum marianum): A concise overview on its chemistry, pharmacological, and nutraceutical uses in liver diseases.": Phytotherapy Research, 32 (2018): 2202 - 2213.
  24. I. Ghzaiel et al. "Protective effects of milk thistle (Sylibum marianum) seed oil and α-tocopherol against 7β-hydroxycholesterol-induced peroxisomal alterations in murine C2C12 myoblasts: Nutritional insights associated with the concept of pexotherapy.": Steroids, 183 (2022).
  25. S. Bhattacharya et al. "Milk Thistle Seeds in Health.": (2020): 429-438.
  26. M. Fallah et al. "Silymarin (milk thistle extract) as a therapeutic agent in gastrointestinal cancer.": Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 142 (2021): 112024 - 112024.
  27. Surisetti Divya et al. "Pharmacognostic, Phytochemical, Ethnobotanical, and Pharmacological Significance of Silybum marianum (Milk Thistle) – A Comprehensive Review.": Current Drug Therapy (2024).
  28. Jennifer Bencze-Nagy et al. "Effects of Dietary Milk Thistle (Silybum marianum) Supplementation in Ducks Fed Mycotoxin-Contaminated Diets.": Veterinary Sciences, 10 (2023).
  29. B. Ali et al. "Effect of Milk Thistle (Silybum marianum (L.) Gaertn) Seed Extract on Bacterial Activities and Growth of Human Liver Cancer Cells.": Journal of Biotechnology Research (2020).
  30. Souha Hammouda et al. "Nigella and Milk Thistle Seed Oils: Potential Cytoprotective Effects against 7β-Hydroxycholesterol-Induced Toxicity on SH-SY5Y Cells.": Biomolecules, 11 (2021).

ミルクシスルオイル (silybum marianum)

aged skin rejuvenation

Pack size options: customised package availabe

DOWNLOAD PRODUCT INFO SHEET
  • ミルクシスル種子の低温圧搾オイルは、必須脂肪酸、トコフェロール(ビタミンE)、ポリフェノール、その他多くの生理活性成分を豊富に含んでいます。

  • このハーブは、化粧品、機能性食品、栄養補助食品、そして生薬の原料として適した薬用植物資源として、再び人気が高まっています。

  • 近年の研究では、メタボリックシンドロームのリスク因子を低減する可能性、肝機能の保護、抗酸化作用や抗炎症作用に加え、神経保護や抗菌作用までも提供し得ることが強調されています。




Benefits *

健康効果 *

  • 代謝および心血管系:動物研究によれば、低温圧搾ミルクシスルオイルの補給は、肥満によって引き起こされる体重増加、高血糖、高血圧、炎症、肝臓の瘢痕化を軽減することが示されています。これは、メタボリックシンドロームの改善や心臓の健康維持に有用である可能性を示唆しています。
  • 肝保護および抗酸化作用:複数の研究で、このオイルが毒素による損傷を防ぎ、酸化ストレスを軽減し、正常な肝機能を回復させることが確認されています。これらの効果は、その高い抗酸化物質含有量に起因するとされています。
  • 抗炎症・抗関節炎作用:ミルクシスルの低温圧搾油は、炎症や関節炎症状を軽減することが示されています。特に若い種子から得られたオイルは、ポリコサノールと呼ばれる有益な成分を多く含むため、より効果的とされています。
  • 神経保護作用:コレステロール由来の有害毒素や酸化ストレスから神経細胞を保護し、脳の健康に寄与することが示されています。
  • 抗菌・抗真菌作用:研究によれば、このオイルは黄色ブドウ球菌、大腸菌、カンジダ属など、複数の有害な細菌や真菌の増殖を抑制する効果があります。
  • 抗がん作用:いくつかの研究では、このオイルが実験室環境において肝臓がんや大腸がんの細胞を中程度に死滅させる能力を持つことが示されており、抗がんの可能性が示唆されています。

Applications

  • 医薬品
  • 化粧品
  • 食品添加物
  • 機能性成分
  • 栄養補助食品(サプリメント)



Contents

成分 (INCI): 100% 低温圧搾ミルクシスル種子油(Silybum marianum oil)。添加物不使用。オーガニック原料の選択も可能。

Story

ミルクシスルの歴史 ― 肝臓の守護者

ラテン名や臨床試験が与えられるずっと以前から、ミルクシスルは地中海の太陽に照らされた丘に自生していました。鮮やかな紫の花と鋭いとげを持つ葉には、白い乳のような筋が走り、古代の癒し手たちはそれを「肝臓を守る聖なる植物」の印と見なしていました。

紀元1世紀のギリシャ医師ディオスコリデスの記録には、ミルクシスルが肝臓や胆汁の流れに良いと記されています。ローマ人は蛇の咬傷や肝臓の不調に用い、葉脈を流れる白い「ミルク」は偶然ではなく、癒しの象徴と考えました。

やがて中世の修道院においても薬草の知識が広まり、ミルクシスルは修道院の庭に欠かせない植物となりました。彼らは「メランコリー(憂鬱)」や肝うっ血を、体液のバランスの乱れに起因するものと考え、その治療に役立てました。

ドイツの伝統医療ではMariendistel(マリアのアザミ)と呼ばれました。伝承によると、葉の白い模様は聖母マリアが幼子イエスに授乳した際にこぼれた乳だとされ、そこから浄化と守護の力を持つ植物として深く敬われるようになりました。

19世紀にはヨーロッパの医師がミルクシスル種子のアルコールチンキを黄疸や胆石、肝炎に使用していました。そして1970年代に入り、研究者たちがシリマリンと呼ばれる有効成分群を抽出したことで、伝統医学と科学の橋渡しが始まりました。

今日、ミルクシスルは肝臓サポートのために最も研究された薬草のひとつとして知られ、細胞を毒素から守り、炎症を抑え、再生を助ける作用が認められています。かつて副産物とされていた低温圧搾の搾りかすも、いまでは食物繊維、タンパク質、抗酸化成分を豊富に含む有用資源として、人間の食事や家畜の栄養に活用されています。

聖なる伝承から臨床科学に至るまで、ミルクシスルは常に肝臓の守護者、そして生命力を支える保護者としての役割を担い続けているのです。



* Scientific References: Milk Thistle Seed Oil

  1. Hsin-Hsueh Shen et al. "Milk thistle seed cold press oil attenuates markers of the metabolic syndrome in a mouse model of dietary-induced obesity..": Journal of food biochemistry (2020): e13522 .
  2. A. Hermenean et al. "Antioxidant and hepatoprotective activity of milk thistle (Silybum marianum L. Gaertn.) seed oil.": Open Life Sciences, 10 (2015).
  3. S. Harrabi et al. "Policosanol composition, antioxidant and anti-arthritic activities of milk thistle (Silybium marianum L.) oil at different seed maturity stages.": Lipids in Health and Disease, 17 (2018).
  4. Heba H. Gaber et al. "Biological in Vitro and in Vivo Studies of the Milk Thistle Seed Oil.": Food and Nutrition Sciences (2022).
  5. Anis Chikhoune et al. "Bioactive Potential of Milk Thistle (Sylibum marianum) Seeds and Applicability of Its Edible Oil in Food Processing.": MGIBR 2024 (2024).
  6. Agata Sumara et al. "Comprehensive Review of Seven Plant Seed Oils: Chemical Composition, Nutritional Properties, and Biomedical Functions.": Food Reviews International, 39 (2022): 5402 - 5422.
  7. W. Meddeb et al. "Cytoprotective Activities of Milk Thistle Seed Oil Used in Traditional Tunisian Medicine on 7-Ketocholesterol and 24S-Hydroxycholesterol-Induced Toxicity on 158N Murine Oligodendrocytes.": Antioxidants, 7 (2018).
  8. G. Dogan et al. "Chemical Composition and Biological Activity of Milk Thistle Seeds (Silybum marianum (L.) Gaertn.).": International Journal of Nature and Life Sciences (2022).
  9. Asmaa Badreddine et al. "Antioxidant and neuroprotective properties of Mediterranean oils: Argan oil, olive oil, and milk thistle seed oil.": Oxidative Stress and Dietary Antioxidants in Neurological Diseases (2020).
  10. P. Oliinyk et al. "Milk Thistle Oil and Its Beneficial Effects on the Liver and Hepatic Diseases.": Journal of Biochemicals and Phytomedicine (2024).
  11. Sameh Maaloul et al. "Characterization of Silybum marianum and Silybum eburneum seed oils: Phytochemical profiles and antioxidant properties supporting important nutritional interests.": PLOS ONE, 19 (2024).
  12. S. Bhattacharya et al. "Milk Thistle ( Silybum marianum L. Gaert.) Seeds in Health.": Nuts and Seeds in Health and Disease Prevention (2011): 759-766.
  13. Sherin Ali et al. "The potential of cultivated milk thistle by-products as cancer chemopreventive and anti-inflammatory drugs.": Egyptian Pharmaceutical Journal, 18 (2019): 411 - 418.
  14. W. Meddeb et al. "Tunisian Milk Thistle: An Investigation of the Chemical Composition and the Characterization of Its Cold-Pressed Seed Oils.": International Journal of Molecular Sciences, 18 (2017).
  15. Abd-El-hady et al. "Morphological, chemical characteristics and antioxidant activity of Egypt grown wild milk thistle (Silybum marianum L.) seeds and evaluates their oil in fast frying process comparing with some vegetable oils.": Middle East Journal of Applied Sciences (2019).
  16. M. Kalinowska et al. "Comparing the extraction methods, chemical composition, phenolic contents and antioxidant activity of edible oils from Cannabis sativa and Silybum marianu seeds.": Scientific Reports, 12 (2022).
  17. Paulina M Opyd et al. "Intestinal, liver and lipid disorders in genetically obese rats are more efficiently reduced by dietary milk thistle seeds than their oil.": Scientific Reports, 11 (2021).
  18. M. Bijak et al. "Silybin, a Major Bioactive Component of Milk Thistle (Silybum marianum L. Gaernt.)—Chemistry, Bioavailability, and Metabolism.": Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry, 22 (2017).
  19. Geir Bjørklund et al. "Milk Thistle (Silybum marianum): Potential Role in Cancer Prevention..": Current medicinal chemistry (2025).
  20. Oumayma Iraqi et al. "Exploring the chemical composition, antioxidant, and antibacterial properties of milk thistle (Silybum marianum L.).": Frontiers in Sustainable Food Systems (2025).
  21. Samantha Drouet et al. "A Green Ultrasound-Assisted Extraction Optimization of the Natural Antioxidant and Anti-Aging Flavonolignans from Milk Thistle Silybum marianum (L.) Gaertn. Fruits for Cosmetic Applications.": Antioxidants, 8 (2019).
  22. V. Valková et al. "MILK THISTLE (SILYBUM MARIANUM): A VALUABLE MEDicinal PLANT WITH SEVERAL THERAPEUTIC PURPOSES.": Journal of Microbiology, Biotechnology and Food Sciences (2020).
  23. L. Abenavoli et al. "Milk thistle (Silybum marianum): A concise overview on its chemistry, pharmacological, and nutraceutical uses in liver diseases.": Phytotherapy Research, 32 (2018): 2202 - 2213.
  24. I. Ghzaiel et al. "Protective effects of milk thistle (Sylibum marianum) seed oil and α-tocopherol against 7β-hydroxycholesterol-induced peroxisomal alterations in murine C2C12 myoblasts: Nutritional insights associated with the concept of pexotherapy.": Steroids, 183 (2022).
  25. S. Bhattacharya et al. "Milk Thistle Seeds in Health.": (2020): 429-438.
  26. M. Fallah et al. "Silymarin (milk thistle extract) as a therapeutic agent in gastrointestinal cancer.": Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 142 (2021): 112024 - 112024.
  27. Surisetti Divya et al. "Pharmacognostic, Phytochemical, Ethnobotanical, and Pharmacological Significance of Silybum marianum (Milk Thistle) – A Comprehensive Review.": Current Drug Therapy (2024).
  28. Jennifer Bencze-Nagy et al. "Effects of Dietary Milk Thistle (Silybum marianum) Supplementation in Ducks Fed Mycotoxin-Contaminated Diets.": Veterinary Sciences, 10 (2023).
  29. B. Ali et al. "Effect of Milk Thistle (Silybum marianum (L.) Gaertn) Seed Extract on Bacterial Activities and Growth of Human Liver Cancer Cells.": Journal of Biotechnology Research (2020).
  30. Souha Hammouda et al. "Nigella and Milk Thistle Seed Oils: Potential Cytoprotective Effects against 7β-Hydroxycholesterol-Induced Toxicity on SH-SY5Y Cells.": Biomolecules, 11 (2021).